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microscopy data (.czi files)  (Carl Zeiss)


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    Carl Zeiss microscopy data (.czi files)
    (A) 3D images of Ren1 c-tdTomato/+ mouse kidney cortex showing renin cells, arterial tree and nerve fibers. The enlarged XY view (right panel) highlights nerve fibers enveloping the renin cells, with fine branching of nerve fibers indicated by arrowheads. Bottom panels depict separate channels. Scale bars: left and bottom panels, 100 µm; enlarged view, 50 µm. (B) Three-dimensional images from Ren1 c+/- ; Ren1 c-Cre ; R26R mTmG mice labeled for renin-lineage cells (GFP), other tissue structures (tdTomato), and nerve fibers. Enlarged XY view highlights nerve fiber arrangement along afferent and efferent arterioles, avoiding glomeruli. Bottom panels depict separate channels. Scale bars: 100 µm. (C) Immunofluorescence staining of Ren1 c-tdTomato/+ mouse kidneys for tyrosine hydroxylase (TH) and tubrin-beta 3 (TUBB3), confirming sympathetic innervation of renin cells. Dashed circle: glomerulus. Scale: 50 µm. (D) Synaptic marker synaptophysin (SYN) co-localized with TUBB3-positive nerve fibers, suggesting synaptic connections with renin cells. Right panels: enlarged views showing colocalization. Dashed circle: glomerulus. Scale bars: left image, 50 µm; right enlarged panels, 10 µm. (E) Electron <t>microscopy</t> image illustrating nerve terminal containing synaptic vesicles (arrowhead), closely associated with a renin-secreting cell containing renin granules (G). Inset: low-magnification view of a renin cell. The main panel is an enlarged view of the region indicated by an asterisk (*). Scale bars: 500 nm. αSMA, α-smooth muscle actin. See also Supplemental Videos 3 and 4.
    Microscopy Data (.Czi Files), supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    microscopy data (.czi files) - by Bioz Stars, 2026-07
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    Images

    1) Product Images from "Renin Cells Drive Kidney Neurovascular Development and Arterial Remodeling when Renin Activity is Deficient"

    Article Title: Renin Cells Drive Kidney Neurovascular Development and Arterial Remodeling when Renin Activity is Deficient

    Journal: bioRxiv

    doi: 10.1101/2025.07.08.663706

    (A) 3D images of Ren1 c-tdTomato/+ mouse kidney cortex showing renin cells, arterial tree and nerve fibers. The enlarged XY view (right panel) highlights nerve fibers enveloping the renin cells, with fine branching of nerve fibers indicated by arrowheads. Bottom panels depict separate channels. Scale bars: left and bottom panels, 100 µm; enlarged view, 50 µm. (B) Three-dimensional images from Ren1 c+/- ; Ren1 c-Cre ; R26R mTmG mice labeled for renin-lineage cells (GFP), other tissue structures (tdTomato), and nerve fibers. Enlarged XY view highlights nerve fiber arrangement along afferent and efferent arterioles, avoiding glomeruli. Bottom panels depict separate channels. Scale bars: 100 µm. (C) Immunofluorescence staining of Ren1 c-tdTomato/+ mouse kidneys for tyrosine hydroxylase (TH) and tubrin-beta 3 (TUBB3), confirming sympathetic innervation of renin cells. Dashed circle: glomerulus. Scale: 50 µm. (D) Synaptic marker synaptophysin (SYN) co-localized with TUBB3-positive nerve fibers, suggesting synaptic connections with renin cells. Right panels: enlarged views showing colocalization. Dashed circle: glomerulus. Scale bars: left image, 50 µm; right enlarged panels, 10 µm. (E) Electron microscopy image illustrating nerve terminal containing synaptic vesicles (arrowhead), closely associated with a renin-secreting cell containing renin granules (G). Inset: low-magnification view of a renin cell. The main panel is an enlarged view of the region indicated by an asterisk (*). Scale bars: 500 nm. αSMA, α-smooth muscle actin. See also Supplemental Videos 3 and 4.
    Figure Legend Snippet: (A) 3D images of Ren1 c-tdTomato/+ mouse kidney cortex showing renin cells, arterial tree and nerve fibers. The enlarged XY view (right panel) highlights nerve fibers enveloping the renin cells, with fine branching of nerve fibers indicated by arrowheads. Bottom panels depict separate channels. Scale bars: left and bottom panels, 100 µm; enlarged view, 50 µm. (B) Three-dimensional images from Ren1 c+/- ; Ren1 c-Cre ; R26R mTmG mice labeled for renin-lineage cells (GFP), other tissue structures (tdTomato), and nerve fibers. Enlarged XY view highlights nerve fiber arrangement along afferent and efferent arterioles, avoiding glomeruli. Bottom panels depict separate channels. Scale bars: 100 µm. (C) Immunofluorescence staining of Ren1 c-tdTomato/+ mouse kidneys for tyrosine hydroxylase (TH) and tubrin-beta 3 (TUBB3), confirming sympathetic innervation of renin cells. Dashed circle: glomerulus. Scale: 50 µm. (D) Synaptic marker synaptophysin (SYN) co-localized with TUBB3-positive nerve fibers, suggesting synaptic connections with renin cells. Right panels: enlarged views showing colocalization. Dashed circle: glomerulus. Scale bars: left image, 50 µm; right enlarged panels, 10 µm. (E) Electron microscopy image illustrating nerve terminal containing synaptic vesicles (arrowhead), closely associated with a renin-secreting cell containing renin granules (G). Inset: low-magnification view of a renin cell. The main panel is an enlarged view of the region indicated by an asterisk (*). Scale bars: 500 nm. αSMA, α-smooth muscle actin. See also Supplemental Videos 3 and 4.

    Techniques Used: Labeling, Immunofluorescence, Staining, Marker, Electron Microscopy



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    (A) 3D images of Ren1 c-tdTomato/+ mouse kidney cortex showing renin cells, arterial tree and nerve fibers. The enlarged XY view (right panel) highlights nerve fibers enveloping the renin cells, with fine branching of nerve fibers indicated by arrowheads. Bottom panels depict separate channels. Scale bars: left and bottom panels, 100 µm; enlarged view, 50 µm. (B) Three-dimensional images from Ren1 c+/- ; Ren1 c-Cre ; R26R mTmG mice labeled for renin-lineage cells (GFP), other tissue structures (tdTomato), and nerve fibers. Enlarged XY view highlights nerve fiber arrangement along afferent and efferent arterioles, avoiding glomeruli. Bottom panels depict separate channels. Scale bars: 100 µm. (C) Immunofluorescence staining of Ren1 c-tdTomato/+ mouse kidneys for tyrosine hydroxylase (TH) and tubrin-beta 3 (TUBB3), confirming sympathetic innervation of renin cells. Dashed circle: glomerulus. Scale: 50 µm. (D) Synaptic marker synaptophysin (SYN) co-localized with TUBB3-positive nerve fibers, suggesting synaptic connections with renin cells. Right panels: enlarged views showing colocalization. Dashed circle: glomerulus. Scale bars: left image, 50 µm; right enlarged panels, 10 µm. (E) Electron <t>microscopy</t> image illustrating nerve terminal containing synaptic vesicles (arrowhead), closely associated with a renin-secreting cell containing renin granules (G). Inset: low-magnification view of a renin cell. The main panel is an enlarged view of the region indicated by an asterisk (*). Scale bars: 500 nm. αSMA, α-smooth muscle actin. See also Supplemental Videos 3 and 4.
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    (A) 3D images of Ren1 c-tdTomato/+ mouse kidney cortex showing renin cells, arterial tree and nerve fibers. The enlarged XY view (right panel) highlights nerve fibers enveloping the renin cells, with fine branching of nerve fibers indicated by arrowheads. Bottom panels depict separate channels. Scale bars: left and bottom panels, 100 µm; enlarged view, 50 µm. (B) Three-dimensional images from Ren1 c+/- ; Ren1 c-Cre ; R26R mTmG mice labeled for renin-lineage cells (GFP), other tissue structures (tdTomato), and nerve fibers. Enlarged XY view highlights nerve fiber arrangement along afferent and efferent arterioles, avoiding glomeruli. Bottom panels depict separate channels. Scale bars: 100 µm. (C) Immunofluorescence staining of Ren1 c-tdTomato/+ mouse kidneys for tyrosine hydroxylase (TH) and tubrin-beta 3 (TUBB3), confirming sympathetic innervation of renin cells. Dashed circle: glomerulus. Scale: 50 µm. (D) Synaptic marker synaptophysin (SYN) co-localized with TUBB3-positive nerve fibers, suggesting synaptic connections with renin cells. Right panels: enlarged views showing colocalization. Dashed circle: glomerulus. Scale bars: left image, 50 µm; right enlarged panels, 10 µm. (E) Electron <t>microscopy</t> image illustrating nerve terminal containing synaptic vesicles (arrowhead), closely associated with a renin-secreting cell containing renin granules (G). Inset: low-magnification view of a renin cell. The main panel is an enlarged view of the region indicated by an asterisk (*). Scale bars: 500 nm. αSMA, α-smooth muscle actin. See also Supplemental Videos 3 and 4.
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    (A) 3D images of Ren1 c-tdTomato/+ mouse kidney cortex showing renin cells, arterial tree and nerve fibers. The enlarged XY view (right panel) highlights nerve fibers enveloping the renin cells, with fine branching of nerve fibers indicated by arrowheads. Bottom panels depict separate channels. Scale bars: left and bottom panels, 100 µm; enlarged view, 50 µm. (B) Three-dimensional images from Ren1 c+/- ; Ren1 c-Cre ; R26R mTmG mice labeled for renin-lineage cells (GFP), other tissue structures (tdTomato), and nerve fibers. Enlarged XY view highlights nerve fiber arrangement along afferent and efferent arterioles, avoiding glomeruli. Bottom panels depict separate channels. Scale bars: 100 µm. (C) Immunofluorescence staining of Ren1 c-tdTomato/+ mouse kidneys for tyrosine hydroxylase (TH) and tubrin-beta 3 (TUBB3), confirming sympathetic innervation of renin cells. Dashed circle: glomerulus. Scale: 50 µm. (D) Synaptic marker synaptophysin (SYN) co-localized with TUBB3-positive nerve fibers, suggesting synaptic connections with renin cells. Right panels: enlarged views showing colocalization. Dashed circle: glomerulus. Scale bars: left image, 50 µm; right enlarged panels, 10 µm. (E) Electron <t>microscopy</t> image illustrating nerve terminal containing synaptic vesicles (arrowhead), closely associated with a renin-secreting cell containing renin granules (G). Inset: low-magnification view of a renin cell. The main panel is an enlarged view of the region indicated by an asterisk (*). Scale bars: 500 nm. αSMA, α-smooth muscle actin. See also Supplemental Videos 3 and 4.
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    (A) 3D images of Ren1 c-tdTomato/+ mouse kidney cortex showing renin cells, arterial tree and nerve fibers. The enlarged XY view (right panel) highlights nerve fibers enveloping the renin cells, with fine branching of nerve fibers indicated by arrowheads. Bottom panels depict separate channels. Scale bars: left and bottom panels, 100 µm; enlarged view, 50 µm. (B) Three-dimensional images from Ren1 c+/- ; Ren1 c-Cre ; R26R mTmG mice labeled for renin-lineage cells (GFP), other tissue structures (tdTomato), and nerve fibers. Enlarged XY view highlights nerve fiber arrangement along afferent and efferent arterioles, avoiding glomeruli. Bottom panels depict separate channels. Scale bars: 100 µm. (C) Immunofluorescence staining of Ren1 c-tdTomato/+ mouse kidneys for tyrosine hydroxylase (TH) and tubrin-beta 3 (TUBB3), confirming sympathetic innervation of renin cells. Dashed circle: glomerulus. Scale: 50 µm. (D) Synaptic marker synaptophysin (SYN) co-localized with TUBB3-positive nerve fibers, suggesting synaptic connections with renin cells. Right panels: enlarged views showing colocalization. Dashed circle: glomerulus. Scale bars: left image, 50 µm; right enlarged panels, 10 µm. (E) Electron <t>microscopy</t> image illustrating nerve terminal containing synaptic vesicles (arrowhead), closely associated with a renin-secreting cell containing renin granules (G). Inset: low-magnification view of a renin cell. The main panel is an enlarged view of the region indicated by an asterisk (*). Scale bars: 500 nm. αSMA, α-smooth muscle actin. See also Supplemental Videos 3 and 4.
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    Image Search Results


    (A) 3D images of Ren1 c-tdTomato/+ mouse kidney cortex showing renin cells, arterial tree and nerve fibers. The enlarged XY view (right panel) highlights nerve fibers enveloping the renin cells, with fine branching of nerve fibers indicated by arrowheads. Bottom panels depict separate channels. Scale bars: left and bottom panels, 100 µm; enlarged view, 50 µm. (B) Three-dimensional images from Ren1 c+/- ; Ren1 c-Cre ; R26R mTmG mice labeled for renin-lineage cells (GFP), other tissue structures (tdTomato), and nerve fibers. Enlarged XY view highlights nerve fiber arrangement along afferent and efferent arterioles, avoiding glomeruli. Bottom panels depict separate channels. Scale bars: 100 µm. (C) Immunofluorescence staining of Ren1 c-tdTomato/+ mouse kidneys for tyrosine hydroxylase (TH) and tubrin-beta 3 (TUBB3), confirming sympathetic innervation of renin cells. Dashed circle: glomerulus. Scale: 50 µm. (D) Synaptic marker synaptophysin (SYN) co-localized with TUBB3-positive nerve fibers, suggesting synaptic connections with renin cells. Right panels: enlarged views showing colocalization. Dashed circle: glomerulus. Scale bars: left image, 50 µm; right enlarged panels, 10 µm. (E) Electron microscopy image illustrating nerve terminal containing synaptic vesicles (arrowhead), closely associated with a renin-secreting cell containing renin granules (G). Inset: low-magnification view of a renin cell. The main panel is an enlarged view of the region indicated by an asterisk (*). Scale bars: 500 nm. αSMA, α-smooth muscle actin. See also Supplemental Videos 3 and 4.

    Journal: bioRxiv

    Article Title: Renin Cells Drive Kidney Neurovascular Development and Arterial Remodeling when Renin Activity is Deficient

    doi: 10.1101/2025.07.08.663706

    Figure Lengend Snippet: (A) 3D images of Ren1 c-tdTomato/+ mouse kidney cortex showing renin cells, arterial tree and nerve fibers. The enlarged XY view (right panel) highlights nerve fibers enveloping the renin cells, with fine branching of nerve fibers indicated by arrowheads. Bottom panels depict separate channels. Scale bars: left and bottom panels, 100 µm; enlarged view, 50 µm. (B) Three-dimensional images from Ren1 c+/- ; Ren1 c-Cre ; R26R mTmG mice labeled for renin-lineage cells (GFP), other tissue structures (tdTomato), and nerve fibers. Enlarged XY view highlights nerve fiber arrangement along afferent and efferent arterioles, avoiding glomeruli. Bottom panels depict separate channels. Scale bars: 100 µm. (C) Immunofluorescence staining of Ren1 c-tdTomato/+ mouse kidneys for tyrosine hydroxylase (TH) and tubrin-beta 3 (TUBB3), confirming sympathetic innervation of renin cells. Dashed circle: glomerulus. Scale: 50 µm. (D) Synaptic marker synaptophysin (SYN) co-localized with TUBB3-positive nerve fibers, suggesting synaptic connections with renin cells. Right panels: enlarged views showing colocalization. Dashed circle: glomerulus. Scale bars: left image, 50 µm; right enlarged panels, 10 µm. (E) Electron microscopy image illustrating nerve terminal containing synaptic vesicles (arrowhead), closely associated with a renin-secreting cell containing renin granules (G). Inset: low-magnification view of a renin cell. The main panel is an enlarged view of the region indicated by an asterisk (*). Scale bars: 500 nm. αSMA, α-smooth muscle actin. See also Supplemental Videos 3 and 4.

    Article Snippet: Raw Zeiss microscopy data (.czi files) were converted to Imaris-compatible files (.ims format) using Imaris File Converter 10.0.0, with tile scan images stitched by Imaris Stitcher 10.0.0.

    Techniques: Labeling, Immunofluorescence, Staining, Marker, Electron Microscopy